Comment · Wed, November 14, 2012
Why do people babble and speak nonsense while rolling??
Original post in this thread
douchechyll · 15 points
So I've rolled several times and I have noticed that at higher doses I tend to babble and say things that make no sense at all. When I'm called out on it I often don't even remember what I had said several seconds earlier. The other night me and my girlfriend ended up having a rambling conversation that made no sense but we remember having the conversation. Anyone have any insight as to why that happens?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb
My guess would be that you've taken such a high dose that your calcium channels are opening too frequently, and for longer than needed. This sends lots of signals through your neurons, bringing up ideas and thoughts at random without control. MDMA increases the level of extracellular glutamate. This is the substance that binds to your NMDA receptors, opening your ion channels and allowing calcium to enter your neurons. The effects you are describing sound like glutamate excitotoxicity causing excessive electrical signaling across your neuronal connections. This is not only rapidly increasing your tolerance to MDMA, but is also lowering the effectiveness of you ion channels and potentially damaging your neurons. LOWER YOUR DOSE! Also, take some magnesium glycinate to modulate your NMDA receptors.
http://web.as.uky.edu/Biology/faculty/cooper/labWWW-PDFs/MDMA%20NMJ.pdf