Comment · Sat, November 10, 2012
How to minimise risks of MDMA? And how often is too often? (x-post from DrugNerds)
Original post in this thread
[deleted] · 37 points
Hello all, I am a 22 y/o female trying to avoid self-fuckuppery while still having a good time. Any advice would be great.
So I took MDMA for the first time three months ago and I've taken it twice since then spaced about a month apart. By the third time I had read a bit around it and was taking after preloading piracetam, taking vitamin C at the same time and 5-HTP afterwards. Clearly MDMA is great and I want to keep taking it but I thought I should nail down how to do it as safely as possible before continuing.
After reading these two posts: http://www.reddit.com/r/Drugs/comments/12v5f8/research_suggests_no_neurotoxicity_in_mdma/ http://www.reddit.com/r/Drugs/comments/12x0a1/pre_and_postloading_supplements_dosage_and_timing/
I am going to bring in green tea, magnesium glycinate, alpha lipoic acid and all of the recommended antioxidants/etc mentioned to try and combat damage as much as possible and make sure body temperature is kept down.
So here are some questions: How can you keep down body temperature in a hot club environment? Does having ice water really help - doesn't suddenly putting something really cold inside you shock the system a bit, or does that not really matte…
What they were answering
Toodlum · 2 points
Just some elaboration on what others have already said:
Pre-loading with piracetam is a good move, just be sure not to take it the same day as the MDMA as it will diminish its effects greatly. Take it in the days leading up to a roll and cease use on the day of.
Vitamin C should be taken in HIGH doses and throughout your entire roll. Animal studies show that only very high doses offer neuroprotection. I would suggest 3000mg at the start, 500mg every hour, and 3000mg after you come down.
Alpha lipoic acid is not the same way, once the brain reaches 'full' gluthianone status, there is no reason to re-dose. I would recommend 50mg at the start of the roll and end of your roll.
Does having ice water really help - doesn't suddenly putting something really cold inside you shock the system a bit, or does that not really matter?
There is a risk of hyponatremia (an imbalance of electrolytes and water in the body) if water consumption is too excessive. This can lead to cerebral edemia (a literal swelling of the brain) and death.
To combat this, you should be consuming electrolytes. MDMA causes a release of ADH which decreases the amount of water lost through urine. Drinking electrolytes, or just plain old salt water, will encourage the kidneys to start working again. This will also make urination much easier.
But make sure salt intake is not too quick or excessive. A quick and…
u/MisterYouAreSoDumb
The half life of alpha lipoic acid is ~30min though. Source
Also, it's bioavailability is between 20% and 38%. I feel 50mg is too low of a dose. I would take 200mg, 4 times over the 6 hour period.
If you have some extra insight into this, I would love to discuss it.