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Why is it not public information that taking any 5-htx agonist daily is likely to cause permanent damage in the body?
Replying to Velocilobstar · Hyperthermia has proven to be the main factor in the cause of MDMA's speculative neuroxicity. Of course the drug can be the cause of it, but behavior can greatly exacerbate the iss…
Hyperthermia is the thing most correlated to the amount of damage. Lower hyperthermia: lower damage. Higher hyperthermia: higher damage. The cause of the hyperthermia is likely due to MDMA or its metabolites, and you can protect from damage even if body temps stay high. Alpha lip…
4-FA and tianeptine
Replying to baronjpetor · Sure, I had it clear that tianeptine is not a SSRE as it was previously believed. However I don't see the link between its effect on opioid receptors (it's only a very weak mu-opio…
Tianeptine's main actions are modulating the glutamate receptors in the CA3 region of the hippocampus. It's essentially a signal transduction modulator between the various types of glutamate receptors; normalizing the scaling of the amplitude ratio of NMDA receptor to AMPA/kainat…