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Commentr/AskDrugNerdsMay 4, 2020

Itraconazole and stimulants

Replying to jenny10000 · Thank you. If for me it is 34 hours then I have worked out that from Saturday, Sunday and today's dose I'll have 25mg left in my system by friday which should be okay. Is there any

Not that I know of offhand.

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Commentr/AskDrugNerdsMay 3, 2020

Itraconazole and stimulants

Replying to jenny10000 · Thank you. Yeah I have seen that and that's why I know I need to be careful with stimulants. The half life is a couple of days with regular use so if I took my last itraconazole We

The half life for a single dose of itraconazole is 17 hours. However, if you have been regularly taking it, that extends out to 34-42 hours. So it stays in your system a long time. That means if you are regularly taking it, it can take up to 2 days to reduce by half in your syste…

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Commentr/AskDrugNerdsMay 3, 2020

Itraconazole and stimulants

Replying to jenny10000 · u/misteryouaresodumb you seem so know your shit...any advice please? So I now found out that amphetamine uses CYP2D6 and I did see somewhere that itraconazole is also a CYP2D6 inh

Yeah, the CYP inhibition likely led to higher levels of amphetamine in your system. However, there are also cases of congestive heart failure with itraconazole. So there might be a direct mechanism there at play. [Congestive heart failure associated with itraconazole](https://www…

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Commentr/AskDrugNerdsJun 26, 2017

R-alpha lipoic acid / racemic alpha lipoic acid?

Replying to Synzael · Hmm well /u/somestranger26 and /u/misteryouaresodumb have told me r and na r are different but maybe I'm misremembering or wrong. You explained it yourself, racemic inactivates it

Non-salt R-ALA is very unstable, and not very bioavailable. Even racemic ALA is more bioavailable and stable than it. NA-R-ALA is better than both, though. That's the sodium salt of R-ALA.

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Commentr/AskDrugNerdsJun 1, 2016

Do SSRI drugs work in severely underweight people?

Replying to cameronhook · /u/Borax /u/shrillthrill /u/misteryouaresodumb can anyone help me? I am so desperate and I don't have any help from doctors and I can't travel.

No, your weight should not make an SSRI ineffective. That study was saying SSRIs did not improve symptoms of anorexia nervosa, not that being underweight affected the efficacy of the drug. Have you ever researched Memantine? I've had hundreds of people with OCD write me saying it…

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