Comment · Sat, October 18, 2025 · ND Owner
Rephyll Piperine content?
Original post in this thread
cate-chola · 5 points
Does ND’s Rephyll (6% β-caryophyllene from Piper nigrum) also contain a significant amount of Piperine? I noticed that the Piperine added to other products is from Piper nigrum so it seems like Rephyll might also contain that compound.
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
It has zero piperine. It's an extract that only pulls over the β-caryophyllene and then microencapsulates it. The other 94% is that patented microencapsulation system. Terpenes like β-caryophyllene exist as oils. They are volatile oils, which is why you don't see more products using them. To get them in a powder form, and to make them more bioavailable, Rephyll uses a patented process called Zeal Technology. It's actually really cool! Have you heard of liposomes? Well Zeal is essentially a way to make extremely bioavailable liposomes into a powder form. It's literally the world's first powdered liposome technology. How it does this is by using a carrier, in this case starch, sunflower lecithin, and tumeric extract, to create the liposome, then removing the water using high-pressure homogenization to form a phospholipic matrix without the water!
So this is similar to the phospholipid bilayer that makes Longvida more bioavailable. However, this process is taking a highly volatile sesquiterpene oil and makes it a much more stable and easy to use powder that improves bioavailability and efficacy. So the other 90-94% is the phospholipid bilayer encasing the β-caryophyllene.