Comment · Sat, November 26, 2022 · ND Owner
Levagen+ PEA piqued my interest
Original post in this thread
avdiyEl · 4 points
https://mindnutrition.com/blog/levagen-the-bodys-most-effective-anti-inflammatory-agent-and-beyond
u/misteryouaresodumb, do you plan on stocking an improved absorption PEA like this? Maybe even developed in-house?
What they were answering
Direct reply to the original post — see the thread post above.
u/MisterYouAreSoDumb · ND Owner
The makers of Levagen have tried to get us to sell it multiple times before. However, it just doesn't make sense to me. The claimed 1.7X improvement in absorption is not enough to justify it, and the study they did to prove that had very high margins of errors on those numbers.
Here are the relevant figures from the study
You can see that the Levagen+ group had an AUC of 1,942 pmol/mL and the standard PEA had an AUC of 1,117 pmol/mL. However, the margin of error on the Levagen+ AUC is +/- 701.1 pmol/mL, and the margin of error on the standard PEA is +/- 485.1 pmol/mL. The differences between those numbers are within each of their margins of errors. There is also a paradoxical point at 120min where the standard PEA had HIGHER plasma levels than the Levagen+. The rapid drop at 90min for the standard PEA, then an abrupt increase to over the other at 120min, makes me suspicious of the accuracy of the numbers or analytical method. They used a triple quad MS, but I'd have to see more detail to determine if the large margin of error is due to that. If the drop at 90min is a measurement error/anomaly, then the difference in AUC is even less. That being said, I am not opposed to the general idea of making a higher bioavailability PEA. It would just have to make more sense, scientifically and economically, than just taking a double dose of our micronized PEA.