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Comment · Sat, June 4, 2022 · ND Owner

Anyone else not been sick since they started their nootropic/supplement journey with ND?

Original post in this thread

skyhighblue340 · 5 points

I haven’t been sick going on a few years now since I started hoarding ND products. Even with other people around me getting sick, even in close proximity. I feel untouchable.

Wondering if other people have had similar experiences.

What they were answering

[deleted] · 3 points

[deleted]

u/MisterYouAreSoDumb · ND Owner

I've actually lost weight since getting sick. However, I am on a very AMPK heavy stack. I also stopped drinking alcohol after getting sick, which is likely the primary reason for the weight loss. I will monitor things over time, though. I took tons of supplements throughout the whole thing, so I think I prevented most of the cytokine shit that leads to long COVID. At least I hope so. I never lost my taste or smell, but my wife did. I am not short of breath or fatigued now. I feel pretty normal, actually. I read some research that people who had good immune responses to COVID actually had it worse in their upper respiratory tract, like I did. However, their body prevented the virus from spreading to other areas, so they are less likely to get long COVID symptoms. It makes sense. If your body is strongly fighting it, you will get stronger localized issues where that fighting is happening. However, that comes with the benefit of not having it get into other organs and cause problems.

The best analogy I can come up with is like guarding a medieval city. If your guards (immune system) are strong, most of the fighting happens at the city walls and gates. Fierce fighting happens there to prevent the invaders from getting in. If you look at the damage to the city walls and gates, it seems like it was a really bad fight. However, the interior of the city was unscathed. However, if you have weak guards, then the invaders get into the city proper. Then you have to fight them in the streets, houses, and buildings. You have to hunt all the invaders down, and they kills citizens and cause damage all over the city. The city walls might not have as much damage, but then you have all this damage spread around the city itself, and that damage needs to be repaired by all sorts of processes. Had you kept the fighting to the city walls, once the battle is over the rest of the city can just go on like normal. In this analogy, the city walls are the mucous membranes of the upper respiratory tract. I think this is why I had it so bad up there, but didn't get the systemic effects that some people do. My body was busy fighting it in my upper respiratory tract, making the symptoms up there really suck. However, now that I am passed it, the rest of my body just goes back to normal. Time will tell if that is right, but based on how I feel right now I think that's the case. There is research out there pointing to this theory being right, though. People who are double vaxxed and boosted seem to have their body keep the infection isolated to the upper respiratory tract, rather than spreading around.

Of course part of this is just that Omicron strains are much more localized to the upper respiratory tract. In fact, Omicron spreads 70X faster in the upper respiratory tract than Delta! However, it spreads 10X less in the lower lungs. This is due to the spike furin cleavage sites on the spike protein of Omicron not being able to bind to the TMPRSS2 protein in the lungs. That was BA.1 Omicron, too. This new BA.2.12.1 strain spreads much much faster than even BA.1 or normal BA.2 Omicron. I am curious to see the scientific data come out on this new variant, as it seems to spread insanely fast in the upper respiratory tract. I mean, I went 0-100 within like 1-2 hours. It took hold and spread faster than pretty much any other sickness I have ever gotten. Our bodies are just not suited to ramping up our immune system that quickly. It means that you can get a massive viral load way before your immune cells can replicated and gear up for battle. Crazy shit these strains are!

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