Comment · Tue, June 15, 2021 · ND Owner
First time trying Sabroxy. No effect.
Original post in this thread
hummermeister · 27 points
Hi today i tried Sabroxy for the first time. I tried 150mg on an empty stomach, waited one hour and felt no effect. I redosed 150 milligrams and after that I still had no effect. Should i try an even higher dose? People have said its potent and that 100mg is a lot for many people, and i have no experience with stims other than one or 2 cups of coffee twice a day, and I wouldnt really say i get any effect from that either. Anyone here who has tried Sabroxy wants to share their experience or has any tips?
What they were answering
_hintergrund_ · 2 points
Why though? I have heard of this but couldn't find an explanation! Is it known why or is it just some experimental knowledge?
u/MisterYouAreSoDumb · ND Owner
The absorption and metabolism of flavonoids is a very complex process. Lots of our findings are from internal experimentation followed by finding research that would explain why certain combos work better than each component individually. It's also not a simple rule. It's not like combining two flavonoids together will always improve the bioavailability of both. The individual flavonoids and combos matter a lot. We are still researching and doing some trial and error, but we have found that certain combos of flavonoids clearly work better than their individual parts. I think some of that is P-clycoprotein inhibition. Some of it is saturation of metabolic enzymes by one flavonoid allows for another to better absorb. Some of it is interactions with intestinal microflora.
https://www.mdpi.com/2072-6643/5/9/3367/pdf