Comment · Mon, March 1, 2021 · ND Owner
Any plan on making nootropics blends ?
Original post in this thread
Rpnot · 3 points
I move a lot and can't take with me all the separates bottles so I rely on all in one blends from other companies. But I love ND and I'm sure that if you guys release pre-made stacks it would be a game changer.
What they were answering
sirsadalot · 3 points
Would you mind elaborating on those things? Or at least a few you can get away with?
And will there be any study-based demonstrations of MicroMag passing the BBB via Sucrose, or is it not worth it? Because I feel like if there was a good enough paper you could compete with Magtein.
u/MisterYouAreSoDumb · ND Owner
I don't want to give away too much, as we are still using those ingredients for upcoming R&D. However, one ingredient we were using originally in the Sleep Support stack was supposed to be an H1 antagonist, which would make people drowsy and fall asleep quickly. It's how ZzzQuil works. Well all the published research we had showed it would work in a similar fashion, and it did... for a couple hours. What the published research didn't tell us was that it then metabolized into a compound that hit norepinephrine. So in our beta testing everyone would fall asleep quickly, but would then wake up 3 hours later sweating and couldn't get back to sleep. This was because it was antagonizing H1 acutely, then metabolizing into something that then stimulated everyone. There is no documentation of this effect anywhere online, and only after some trial and error did we pinpoint which ingredient it was, then found an obscure paper discussing the metabolism to this other compound. So when you find good research on something that seems to be good for sleep, you might actually find something quite the opposite when you actually take it.
We don't own the patent on Micromag. That's an Italian company. They would have to be the ones funding a study on that, and BBB permeability studies are not cheap. Perhaps they will at some point, but I can't say for sure. However, I will say there is no reason it wouldn't pass the BBB. Magtein is just magnesium chelated to threonic acid with a coordinate bond. Those are stronger bonds than ionic, so they won't dissociate in the GI tract. However, they are not as strong as covalent bonds. They will dissociate in serum. So Magtein's ability to get magnesium to the brain is not due to the chelate transporting it across the brain, but merely getting enough magnesium into serum. Getting enough magnesium into your blood will result in increases in magnesium in the brain, regardless of how you got it into the blood.
https://www.ncbi.nlm.nih.gov/books/NBK507259/
So it is not some super secret sauce to get magnesium to the brain. If you get high enough plasma levels of magnesium in your body, it will transport across the BBB and into the brain. The threonic acid in Magtein is just providing some other nootropic effect as well. So the counter-acid is leading to effects apart from the magnesium. In theory you could take Micromag and threonic acid and get the same effects.