Comment · Sat, October 10, 2020 · ND Owner
🔬 Curowhite and the Color of Curcumin 🔬
Original post in this thread
MisterYouAreSoDumb · 62 points
We have been getting a lot of confusion and questions on the color of Curowhite on our Facebook page, so I figured I would make a post here to address it. I am sure some people here are curious as well. To start, one of the major questions we have been getting is whether Curowhite is bleached to get rid of the color. I think many people are unaware of just how color works, which is why many people immediately jump to what they have experienced before. Many people have seen how chlorine bleach gets rid of color, so they fall back to that. I'll go through the details to clear things up.
What is color? Well color is simply our eyes interpreting the wavelengths of light being reflected back to us from an object. If an object is white, that means that the entire spectrum of visible light is being reflected back to our eyes. If we were to take out part of that spectrum before it reflected back to our eyes, we would see it as a specific color. In curcumin's case, we take out the blue hues, which means our eyes see the curcumin as orange. If we remove all wavelengths, we see black. It's all just our eyes interpreting the wavelengths of light being reflected back to us by objects.
So why…
What they were answering
Tyler_too_cold · 2 points
Curcumin inhibits Dht. You guys think curuwhite would do the same?
u/MisterYouAreSoDumb · ND Owner
Curcumin's effects on DHT are complex.
https://sci-hub.do/10.1021/jm020200g
The parental compound, curcumin(1), was inactive in all cases. However, dimethylated curcumin (4) showed significant antagonistic activity(reducing 70% of DHT-induced AR activity) when assayed in PC-3 cells transfected with wild-type AR(wt.AR) and was more potent than HF (which reduced16% of DHT-induced AR activity, Figure 3A). Compound4also showed the highest antagonist activity when assayed in DU-145 cells transfected with a mutant LNCaP AR and ARA70 (showing a 45% reduction in DHT-induced AR activity, Figure 3B), indicating thatcompound4is an effective antagonist for both wt.AR and mutant AR.
So curcumin has no effect on DHT synthesis, but some of its derivatives do. Curcumin itself does have protective effects in relation to DHT, but those appear to be different mechanisms than 5AR inhibition. When we hydrogenate the curcuminoids, it is anyone's guess how that affects the DHT mechanisms. We can only speculate till we have more data.