Comment · Wed, June 24, 2020 · ND Owner
Ever considered a Passionflower extract?
Original post in this thread
Berengersbottle · 12 points
Hey folks!
I found some interesting studies on passionflower displaying sedative qualities. I’ll post one right here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941540/
That study has links to a number of other helpful studies as well.
This one seems like it could be a real powerhouse natural extract,so I tried an extract from the vitamin shoppe. (Couldn’t find another vendor) It had some weird effects. Definitely sedative, but also stimulatory, as if my body was sluggish but my mind was kind of racing (i’m sure I consumed caffeine that day so take it as you will). Surprised by the muddled results, I took another cap, which just put me in a bad mood - sedated but now agitated. I repeated this experiment and got the same results. Even more surprisingly, the extract seems to prevent me from falling asleep, which makes 0 sense.
The research and online testimonials make me think that it’s probably a problem with the extract I got (solaray). So I wanted to see if you guys had one in the pipeline.
Thanks!
What they were answering
Darkhorseman81 · 1 points
All I read about was fertility, not the testosterone effects. Boosts sperm production and quality in men and animals. Helps with fertility problems in women, too.
Can't remember the exact mechanism of how it worked. I'll check when I'm on my other computer. I do vaguely remember its a powerful aromatase inhibitor, so it may be estrogen and testosterone.
Benzoflavone seems more bioavailable.
u/MisterYouAreSoDumb · ND Owner
The issue is bioavailability.
These results can be explained by the fact that chrysin has low oral bioavailability, mainly because of extensive metabolism and efflux of metabolites back into the intestine for hydrolysis and fecal elimination.
So it might help if you can get it into systemic circulation. That would require some different formulation, though.